WebFeb 27, 2015 · We previously demonstrated that the synthetic analog of dsRNA poly(I:C) induces apoptosis in the androgen-dependent PCa cell line LNCaP in a TLR3-dependent … WebShort synthetic analog of dsRNA, size 25 mg. Polyinosinic-polycytidylic acid (poly (I:C)) is a synthetic analog of double stranded RNA (dsRNA), a molecular pattern associated with …
RNAi and double-strand RNA - Genes & Development
WebJun 30, 2024 · dsRNA, poly(IC), whereas 5mM 2AP did not inhibit TSLP and partially inhibited IL-8 (Figure 1a). The results for BFA at the protein level (Figure 1a) were supported by analysis at the mRNA level showing that BFA completely inhibited the poly(IC)-induced gene expression of cytokines (TSLP, IFN-b, and IL-6) and chemokines (CXCL8/IL-8, … WebNov 7, 2011 · To obtain further validation for type-I IFN signaling induced by poly ICLC in vivo, freshly isolated PBMCs from healthy volunteers were cultured with 10 µg/ml IFN-α … high rise condos for sale dallas tx
Activation of the NLRP3 inflammasome by intracellular poly I:C
WebThe ligand of choice for TLR3 is a synthetic analog of dsRNA known as polyinosinic-polycytidylic acid (poly (I:C) or poly (rI):poly (rC)). Poly (I:C) comprises a strand of inosine … WebDec 7, 2009 · Microbial components play a major role in activating innate and adaptive immune responses by triggering pattern recognition receptors (Ishii et al., 2008).Poly(I:C) … Webparallel, a synthetic form of dsRNA, poly(I):poly(C) [poly(I:C)], was transfected as a positive control. As reported (10), dsRNA but not ssRNA induced IFN- expression in Huh-7 cells (Fig. ... (RIG-IC) together with the IFN- promoter luciferase reporter, and we examined them for IFN- promoter activity with and without transfection of high rise condos for sale atlanta ga