Rbm38 in cancer: role and mechanism

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WebRBM38 in cancer: role and mechanism Author: Cheng Zou, Ying Wan, Lingjing He, Jin Hai Zheng, Yang Mei, Junfeng Shi, Min Zhang, Zhiqiang Dong, Dingxiao Zhang Source: Cellular … WebMETHODS: In the present study, we investigated the role and molecular mechanism of misregulation in the p53-mdm2 loop function by RBM38 in HCC. First we investigated the correlation of RBM38 activity and p53-mdm2 loop function in liver cancer cells and HCC tissues by western blot and quantitative RT-PCR.

Sci-Hub RBM38 in cancer: role and mechanism. Cellular and …

WebA RBM38 suppresses cell proliferation via destabilizing oncogene MYC and stabilizing TS PTEN through AREs in their 3 ... role and mechanism Cancer is the second leading cause of death globally. WebHepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Recent studies reported that lncRNA LINC00473 (LNC473) was involved in cancer progression. However, the clinical significance and functional role of LNC473 in HCC progression is still unknown. In the present study, we found that the LNC473 expression ... early head start in philadelphia

Molecular Landscape of Induced Reprogramming: A Dissertation

WebApr 12, 2024 · Fig. 1: USP1 is an important regulator of Hippo signaling activity, and its expression is elevated in human hepatocellular carcinoma. A The flowchart shows the siRNA screening procedure for ... WebThis reduction was shown to require the N- and C-terminal regions of Rbm38, along with an important role being played by the RNA-recognition motif of Rbm38. ... Cancer Res. 2014, 12, 359–369. ... A schematic model of the mechanism by which Rbm38 suppresses the transcription defect caused by splicing deficiency. cst holdings llc

Rbm38 Reduces the Transcription Elongation Defect of the

RBM38 Is a Direct Transcriptional Target of E2F1 that Limits E2F1 ...

WebAutophagy plays a complex role in tumor cells; studies have shown that autophagy can both inhibit cancer onset and promote advanced tumor growth. 4 Increasing evidence shows that cancer cells are more dependent on autophagy than normal cells, and this dependence may be further strengthened during the treatment process. 5 An increasing number of research … WebAug 22, 2024 · Breast cancer is the most common malignancy in females worldwide (Chen et al, 2016; Siegel et al, 2016), and the metastasis accounts for the majority of deaths from breast cancer.One potential mechanism for invasion and metastasis in breast cancer is due to the occurring of epithelial–mesenchymal transition (EMT) that allows the polarised … early head start indianaWebNov 19, 2024 · Breast cancer (BC) is a common type of malignant tumor that is frequently accompanied by drug resistance, which is a significant challenge in the treatment of BC. Adriamycin (ADM) is a commonly used drug for the treatment of BC. The aim of the present study was to demonstrate the association between RNA binding motif protein 38 … early head start in grand prairie tx

"WebPeptidyl–prolyl isomerases (PPIase) facilitate the cis–trans interconversion of the peptidyl–prolyl bond and in such way affect protein folding. Pin1 is a PPIase, which specifically recognizes phosphorylated S/T-P bonds. The transcription factor TFIIH mediates phosphorylation of the retinoic acid receptor alpha (RARα) at position Ser 77.In the … " - Rbm38 in cancer: role and mechanism

Rbm38 in cancer: role and mechanism

Role of dietary iron revisited: in metabolism, ferroptosis and ...

WebTo systemically study the role of RBPs in BAT, we profiled >400 RBPs in different adipose depots and identified Y-box binding protein 2 (Ybx2) as a novel regulator in BAT activation. http://lcgdbzz.org/en/article/doi/10.3969/j.issn.1001-5256.2024.04.032

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WebSep 1, 2012 · Abstract. The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes and is a critical downstream target of the tumor suppressor pRB. The pRB/E2F pathway is defective in most human tumors, resulting in deregulated E2F activity that induces uncontrolled cell proliferation, a hallmark of tumor … WebHepatocellular carcinoma (HCC) is the most common type of liver cancer in China, and the development and progression of HCC is a complex pathological process. As a new way of cell death, ferroptosis has huge potential in the treatment of HCC. This article introduces the mechanism of action of the tumor suppressor p53 in regulating ferroptosis and briefly …

WebApr 11, 2024 · Moreover, specific inhibitors of c-Myc transcriptional activity inhibited RBM38-induced suppression of growth, implying that RBM38 acts as a tumor suppressor … WebNov 17, 2013 · SFN suppressed both COX-2 mRNA and protein levels by inhibiting NF-κB DNA-binding to the COX-2 promoter. It is known that COX-2 plays a role in cell proliferation, metastasis, and angiogenesis, and thus recent findings suggest that targeting COX-2 through p38 MAPK is a novel mechanism for cancer chemoprevention by SFN in human …

WebOct 1, 2024 · Despite their abundance and several large-scale studies showing their contribution to the evolution of gene-regulatory networks, their role in physiology and various diseases, including cancer, remains relatively rare [2,7,8]. The tumor suppressor p53 is the most commonly mutated gene in human cancers. WebJan 1, 2024 · Role and mechanism of RBM38 in inhibiting BCa cell growth and metastasis. A RBM38 suppresses cell proliferation via destabilizing oncogene MYC and stabilizing TS …

WebJul 24, 2024 · This mechanism is similar to eIF2 alpha phosphorylation ... (Gerlitz et al., 2002; Tinton et al., 2005) or cleavage of scaffolding need to increase our understanding on the role of sequences and ... RNA unique RNA binding domain indicated as a K-homology domain binding motif 38 (RBM38) is an RBP that is ...

WebMar 9, 2024 · Results report that RBM38 mediates direct inhibition of c-Myc expression, which in turn suppresses RBM38 expression. Thus, it can be concluded that RBM38 and c … early head start in spanishWebApr 8, 2024 · Extrachromosomal circular DNAs (eccDNAs) participate in tumorigenesis and tumor progression. However, the role and mechanism of eccDNAs have yet to be elucidated in non-small cell lung cancer (NSCLC). early head start jefferson city moWebApr 7, 2024 · This mechanism is strongly related to inactivation of Rb1 by the HPV E7 protein [19,20]. Not all mechanisms associated with p16 expression are known in cancers. Although many studies have reported on the prognostic role of the decreased or increased p16 expression, the results are often conflicting . early head start jackson miWebHere, we review the evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. Genetic studies in mice deficient … early head start infant classroom scheduleWebau:"Braunschweig, Ulrich" (32) : 20 50 100 20 50 100. 1 - 20 de 32 csthomasreuters.com support downloadsWebJul 8, 2024 · Here, we review the evidence that RBM38, an intensively studied RBP, frequently plays a tumor-suppressive role in multiple human cancer types. Genetic studies … early head start jefferson county wvWebOct 25, 2011 · RBM38 in cancer: role and mechanism. 08 July 2024. Cheng Zou, Ying Wan, ... and wt p53 status, suggesting a tumour suppressive role of RBM38 in breast cancer . ... cst histone